Low Dose Naltrexone

We Can Help Regulate Your Dysfunctional Immune System

Low Dose Naltrexone reduces pain and fights inflammation. It is used to treat cancers, autoimmune diseases, chronic pain, and mental health issues.

How Low Dose Naltrexone Works

Low Dose Naltrexone(LDN) is most commonly being used for Chronic Fatigue Syndrome, multiple sclerosis, myalgic encephalopathy, autoimmune thyroid diseases, and various cancers. Many autoimmune diseases seem to respond to LDN. This is a wide range of diseases, and many clinicians will find it difficult to understand how one drug can have a positive effect on all these pathologies.

The first thing to understand is that naltrexone – the drug in LDN – comes in a 50:50 mixture of 2 different shapes (called isomers). It has been recently discovered that one particular shape binds to immune cells, whilst the other shape binds to opioid receptors. Although consisting of the same components, the two isomers appear to have different biological activities.

Summary of Low Dose Naltrexone In Action

10 years of research summarize that LDN works because Levo-Naltrexone is an antagonist for the opiate/endorphin receptors which causes:

  • increased endorphin release
  • Increased endorphins modulate the immune response
  • This reduces the speed of unwanted cells growing. Dextro-Naltrexone is an antagonist for at least one, if not more immune cells
  • Antagonises “TLR,” suppressing cytokine modulated immune system
  • Antagonises TLR-mediated production of NF-kB – reducing inflammation, potentially downregulating oncogenes

Taking Naltrexone in larger doses of 50-300mg seems to negate the immunomodulatory effect by overwhelming the receptors, so for the effect to work, the dose must be in the range of 0.5-10mg, usually maxing at 4.5mg in clinical experience.

Addiction & Recovery Treatments Franklin, Tennessee

At Rejuvenage MD. Our team is dedicated to the health and well-being of your addictions and can help you on your journey to recovery. Call our offices to speak with a representative or schedule a consultation online today!

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